https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33455 Healthy Dads, Healthy Kids” randomized controlled trials, which tested the efficacy and effectiveness of a socio-culturally targeted program that engages fathers to improve their own health and the health of their children. The paper concludes with a series of recommendations for recruiting and engaging fathers and a summary of directions for future research.]]> Wed 31 Aug 2022 09:54:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24304 485) (P < 0.01), p-PDPK-1 (Ser⁴¹) (P < 0.05), and PKCζ (P < 0.05) was higher in the PCUN and PIUN groups, and hepatic PDK4 (P < 0.001) and CPT-1 (P < 0.05) protein abundance was also higher in the PIUN twin fetus. We also found that the expression of a number of microRNAs was altered in response to PCUN or PIUN and that there is evidence that these changes may underlie the changes in the protein abundance of key regulators of hepatic fatty acid β-oxidation in the PCUN and PIUN groups. Therefore, embryo number and the timing of maternal undernutrition in early pregnancy have a differential impact on hepatic microRNA expression and on the factors that regulate hepatic fatty acid oxidation and lipid synthesis.]]> Wed 28 Feb 2024 15:22:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42021 Wed 28 Feb 2024 14:40:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40265 Wed 28 Feb 2024 14:36:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26668 Wed 24 May 2023 11:37:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27917 Wed 24 May 2023 11:32:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42520 Wed 24 Aug 2022 11:25:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37515 Wed 23 Aug 2023 09:36:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37670 Wed 22 Mar 2023 17:08:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28095 Wed 22 Mar 2023 16:25:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25573 Wed 22 Mar 2023 16:22:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26369 Wed 22 Mar 2023 16:20:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27946 Wed 22 Mar 2023 16:18:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43496 Wed 21 Sep 2022 16:12:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37301 Wed 20 Jan 2021 17:34:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44656 Wed 19 Oct 2022 10:02:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28168 Wed 13 Mar 2024 18:28:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42016 Wed 13 Mar 2024 18:27:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40253 80 h per week on care and work) and often or always rushing are barriers to physical activity and rushing is associated with poorer self-rated and mental health. Exploring their social patterning, we find that time-poor people have higher incomes and more time control. In contrast, rushing is linked to being a woman, lone parenthood, disability, lack of control and work-family conflicts. We supply a methodology to support quantitative investigations of time, and our findings underline time's dimensionality, social distribution and potential to influence health.]]> Wed 13 Mar 2024 18:26:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43015 Wed 09 Aug 2023 12:26:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43500 Wed 07 Feb 2024 17:15:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49046 Wed 03 May 2023 14:09:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25008 Tue 30 Aug 2022 14:27:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30640 Tue 30 Aug 2022 14:17:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30204 Tue 28 Feb 2023 10:27:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25410 Tue 27 Sep 2022 13:53:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32419 Tue 27 Sep 2022 09:41:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50025 Tue 27 Jun 2023 16:47:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50026 Tue 27 Jun 2023 16:47:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30018 Tue 20 Sep 2022 14:49:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44627 Tue 18 Oct 2022 11:22:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44626 Tue 18 Oct 2022 11:11:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50315 Tue 18 Jul 2023 12:37:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19605 AGTR1 and AGTR2 polymorphisms with preeclampsia and whether these are affected by environmental factors and fetal sex. Methods: Overall 3234 healthy nulliparous women, their partners and babies were recruited prospectively to the SCOPE study in Adelaide and Auckland. Data analyses were confined to 2121 Caucasian parent-infant trios, among whom 123 had preeclamptic pregnancies. 1185 uncomplicated pregnancies served as controls. DNA was extracted from buffy coats and genotyped by utilizing the Sequenom MassARRAY system. Doppler sonography on the uterine arteries was performed at 20 weeks' gestation. Results: Four polymorphisms in AGTR1 and AGTR2 genes, including AGTR1 A1166C, AGTR2 C4599A, AGTR2 A1675G and AGTR2 T1134C, were selected and significant associations were predominately observed for AGTR2 C4599A. When the cohort was stratified by maternal BMI, in women with BMI ≥ 25 kg/m2, the AGTR2 C4599A AA genotype in mothers and neonates was associated with an increased risk for preeclampsia compared with the CC genotype [adjusted OR 2.1 (95% CI 1.0–4.2) and adjusted OR 3.0 (95% CI 1.4–6.4), respectively]. In the same subset of women, paternal AGTR2 C4599A A allele was associated with an increased risk for preeclampsia and uterine artery bilateral notching at 20 weeks' gestation compared with the C allele [adjusted OR 1.9 (95% CI 1.1–3.3) and adjusted OR 2.1 (95% CI 1.3–3.4), respectively]. Conclusion: AGTR2 C4599A in mothers, fathers and babies was associated with preeclampsia and this association was only apparent in pregnancies in which the women had a BMI ≥ 25 kg/m2, suggesting a gene–environment interaction.]]> Tue 14 Nov 2023 13:47:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22319 Aedes aegypti mosquitoes with the bacteria Wolbachia has been proposed as an innovative new strategy to reduce the transmission of dengue fever. Field trials are currently being undertaken in Queensland, Australia. However, few mathematical models have been developed to consider the persistence of Wolbachia-infected mosquitoes in the wild. This paper develops a mathematical model to determine the persistence of Wolbachia-infected mosquitoes by considering the competition between Wolbachia-infected and non-Wolbachia mosquitoes. The model has four steady states that are biologically feasible: all mosquitoes dying out, only non-Wolbachia mosquitoes surviving, and two steady states where non-Wolbachia and Wolbachia-infected mosquitoes coexist. The stability of the steady states is determined with respect to the key parameters in the mosquito life cycle. A global sensitivity analysis of the model is also conducted. The results show that the persistence of Wolbachia-infected mosquitoes is dominated by the reproductive rate, death rate, maturation rate and maternal transmission. For the parameter values where Wolbachia persists, it dominates the population, and hence the introduction of Wolbachia has great potential to reduce dengue transmission.]]> Tue 14 Nov 2023 13:41:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43169 Tue 13 Sep 2022 16:03:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43109 Tue 13 Sep 2022 13:22:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42894 Tue 06 Sep 2022 14:32:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42893 6 months post-injury. Six studies identified participants with upper limb spasticity. Methodological quality of psychometric properties ranged from poor to excellent. Best evidence synthesis determined moderate positive evidence for using the ARAT with people without limb spasticity: intra-rater reliability (ICC 0.71 (95% CI 0.53–0.89) to 0.99 (95% CI 0.98, 0.99)); responsiveness (ROC curve 0.72–0.88, SRM 0.89); and regarding construct validity, it is a valid measure of activity limitation. Limited evidence for psychometric properties of the ARAT were found when used with people with upper limb spasticity for construct validity and responsiveness (ES 0.55–0.78). Gaps in evidence were found for inter and test–retest reliability, measurement error, content validity, structural validity, floor and ceiling effects. Conclusions: The ARAT is an appropriate measure of activity limitation post-stroke and should be considered for use with people with TBI; evidence for people with upper limb spasticity is limited. Gaps and mixed limited to moderate evidence for psychometric properties in neurorehabilitation mean further research is required.]]> Tue 06 Sep 2022 14:25:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42870 Tue 06 Sep 2022 09:38:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42869 Tue 06 Sep 2022 09:31:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34248 Thu 30 Mar 2023 18:42:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14194 Thu 30 Mar 2023 17:33:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24160 Thu 30 Mar 2023 17:25:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33786 -8 with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.]]> Thu 30 Mar 2023 15:49:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50033 T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11-1.19, P = 8.88 x 10-16) and among familial cases (OR: 1.24, 95% CI: 1.16-1.32, P = 6.19 x 10-11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.]]> Thu 29 Jun 2023 13:56:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43039 4 standard drinks on a single occasion), and (ii) the total number of alcoholic drinks consumed in the past year, adjusted for a range of potential child, parent, family, and peer covariates. Results: Fifty percent of adolescents reported alcohol use and 36% reported bingeing at wave 5 (mean age 16.9 years), and the mean age of initiation to alcohol use for drinkers was 15.1 years. Age of initiation was significantly associated with binge drinking and total quantity of alcohol consumed in unadjusted and adjusted models. Age of first drunkenness was associated with total quantity of alcohol consumed in unadjusted models but not adjusted models and was not associated with subsequent bingeing. Conclusions: Initiating alcohol use earlier in adolescence is associated with an increased risk of binge drinking and higher quantity of consumption in late secondary school, supporting an argument for delaying alcohol initiation for as long as possible to reduce the risk for problematic use in later adolescence and the alcohol-related harms that may accompany this use.]]> Thu 24 Aug 2023 09:26:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42975 Thu 22 Jun 2023 08:51:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50344 Thu 20 Jul 2023 14:26:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48973 Thu 20 Apr 2023 12:01:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42102 n=28) received access to an online calorie tracking program, smartphone app, three telephone counselling calls with a dietitian and written material. Women in two comparison groups (CI and C2) (n=48; n=43) were from the control (C1) and intervention (C2) arms of InFANT Extend and received no additional support. Weight and waist circumference were measured objectively. Written surveys assessed diet and physical activity. Sedentary behaviour was self-reported. Linear and logistic regression assessed changes in outcomes between groups from 9 to 18 months postpartum. Results: Mean PPWR decreased in the (I) group (-1.2kg) and the C2 group (-1.2kg), although the changes were not significant. Mean waist circumference for all groups exceeded recommendations at baseline but decreased to below recommendations for women in the (I) group (78.3cm) and significantly for the (I) group (-6.4cm) compared to C1 (-1.1cm; P=0.002) and C2 (-3.3cm; P=0.001). Changes in diet, physical activity or sedentary behaviour were not significant. Conclusions: The online intervention reported in the present study shows promise with respect to reducing waist circumference in postpartum women. Further evidence of strategies that may improve weight and related behaviours in this target group is needed.]]> Thu 18 Aug 2022 13:52:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40201 Thu 14 Jul 2022 15:15:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42945 Thu 08 Sep 2022 09:42:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30842 5 years. Forty-five percent of patients were classified as obese (BMI ≥ 30 kg/m2, mean (SD) BMI was 31 ± 7 kg/m2), with a mean waist circumference of 104 ± 19.4 cm (SD). The most frequent patient nominated treatment goals related to physical activity (39%), followed by nutritional goals (23%). Traditionally, pain management programs have included physical, psychosocial, and medical, but not nutritional, interventions. By contrast, patients identified and reported important nutrition-related treatment goals. There is a need to test nutrition treatment pathways, including an evaluation of dietary intake and nutrition support. This will help to optimize dietary behaviors and establish nutrition as an important component of multidisciplinary chronic pain management.]]> Mon 26 Sep 2022 14:38:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43582 99mTc-carbon (‘Technegas’), a clinical V-SPECT modality featuring smaller radioaerosol particles with less clumping. Methods: Eleven lung cancer radiotherapy patients with early stage (T1/T2N0) disease received treatment planning four-dimensional CT (4DCT) scans paired with Technegas V/Q-SPECT/CT. For each patient, we applied three different CTVI methods. Two of these used deformable image registration (DIR) to quantify breathing-induced lung density changes (CTVI_DIR-HU), or breathing-induced lung volume changes (CTVI_DIR-Jac) between the 4DCT exhale/inhale phases. A third method calculated the regional product of air-tissue densities (CTVI_HU) and did not involve DIR. Corresponding CTVI and V-SPECT scans were compared using the Dice similarity coefficient (DSC) for functional defect and nondefect regions, as well as the Spearman's correlation r computed over the whole lung. The DIR target registration error (TRE) was quantified using both manual and computer-selected anatomic landmarks. Results: Interestingly, the overall best performing method (CTVI_HU) did not involve DIR. For nondefect regions, the CTVI_HU, CTVI_DIR-HU, and CTVI_DIR-Jac methods achieved mean DSC values of 0.69, 0.68, and 0.54, respectively. For defect regions, the respective DSC values were moderate: 0.39, 0.33, and 0.44. The Spearman r-values were generally weak: 0.26 for CTVI_HU, 0.18 for CTVI_DIR-HU, and −0.02 for CTVI_DIR-Jac. The spatial accuracy of CTVI was not significantly correlated with TRE, however the DIR accuracy itself was poor with TRE > 3.6 mm on average, potentially indicative of poor quality 4DCT. Q-SPECT scans achieved good correlations with V-SPECT (mean r > 0.6), suggesting that the image quality of Technegas V-SPECT was not a limiting factor in this study. Conclusions: We performed a validation of CTVI using clinically available 4DCT and Technegas V/Q-SPECT for 11 lung cancer patients. The results reinforce earlier findings that the spatial accuracy of CTVI exhibits significant interpatient and intermethod variability. We propose that the most likely factor affecting CTVI accuracy was poor image quality of clinical 4DCT.]]> Mon 26 Sep 2022 10:33:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43579 4DCBCT) can complement existing 4DCT-based methods (CTVI^4DCT) to track lung function changes over a course of lung cancer radiation therapy. However, the accuracy of CTVI^4DCBCT needs to be assessed since anatomic 4DCBCT has demonstrably poor image quality and small field of view (FOV) compared to treatment planning 4DCT. We perform a direct comparison between short interval CTVI^4DCBCT and CTVI^4DCT pairs to understand the patient specific image quality factors affecting the intermodality CTVI reproducibility in the clinic. Methods and materials: We analysed 51 pairs of 4DCBCT and 4DCT scans acquired within 1 day of each other for nine lung cancer patients. To assess the impact of image quality, CTVIs were derived from 4DCBCT scans reconstructed using both standard Feldkamp-Davis-Kress backprojection (CTVI4DCBCT/FDK) and an iterative McKinnon-Bates Simultaneous Algebraic Reconstruction Technique (CTVI4DCBCT/MKBSART). Also, the influence of FOV was assessed by deriving CTVIs from 4DCT scans that were cropped to a similar FOV as the 4DCBCT scans (CTVI4DCT/crop), or uncropped (CTVI4DCT/uncrop). All CTVIs were derived by performing deformable image registration (DIR) between the exhale and inhale phases and evaluating the Jacobian determinant of deformation. Reproducibility between corresponding CTVI^4DCBCT and CTVI^4DCT pairs was quantified using the voxel-wise Spearman rank correlation and the Dice similarity coefficient (DSC) for ventilation defect regions (identified as the lower quartile of ventilation values). Mann–Whitney U-tests were applied to determine statistical significance of each reconstruction and cropping condition. Results: The (mean ± SD) Spearman correlation between CTVIRDCBCT/FDK and CTVI4DCT/uncrop was 0.60 ± 0.23 (range −0.03–0.88) and the DSC was 0.64 ± 0.12 (0.34–0.83). By comparison, correlations between CTVI4DCBCT/MKBSART and CTVI4DCTuncrop showed a small but statistically significant improvement with = 0.64 ± 0.20 (range 0.06–0.90, P = 0.03) and DSC = 0.66 ± 0.13 (0.31–0.87, P = 0.02). Intermodal correlations were noted to decrease with an increasing fraction of lung truncation in 4DCBCT relative to 4DCT, albeit not significantly (Pearson correlation R = 0.58, P = 0.002). Conclusions: This study demonstrates that DIR based CTVIs derived from 4DCBCT can exhibit reasonable to good voxel-level agreement with CTVIs derived from 4DCT. These correlations outperform previous cross-modality comparisons between 4DCT-based ventilation and nuclear medicine. The use of 4DCBCT scans with iterative reconstruction and minimal lung truncation is recommended to ensure better reproducibility between 4DCBCT- and 4DCT-based CTVIs.]]> Mon 26 Sep 2022 10:30:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43577 Skin detectors were an effective tool for measuring dose delivered to the anterior rectal wall in real time during prostate SBRT boost treatments for the purpose of both ensuring the rectal doses remain within acceptable limits during the treatment and for the verification of final rectal doses.]]> Mon 26 Sep 2022 10:27:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47589 Mon 23 Jan 2023 14:49:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47483 Mon 23 Jan 2023 11:47:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42333 Mon 22 Aug 2022 11:06:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24945 Mon 20 Mar 2023 13:00:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24879 Mon 20 Mar 2023 12:52:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27929 Mon 20 Mar 2023 12:45:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43052 Mon 12 Sep 2022 14:37:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43044 Mon 12 Sep 2022 12:38:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43040 Mon 12 Sep 2022 12:10:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43034 Mon 12 Sep 2022 11:49:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43033 Mon 12 Sep 2022 11:42:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40241 Mon 08 Aug 2022 13:51:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42856 Mon 05 Sep 2022 16:01:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42851 Mon 05 Sep 2022 15:40:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42830 Mon 05 Sep 2022 12:03:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42826 Mon 05 Sep 2022 11:56:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42822 Mon 05 Sep 2022 11:49:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42808 Mon 05 Sep 2022 09:57:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42806 27-IGF-II inhibits IGF-I:IGFBP:VN-stimulated breast cancer cell migration and proliferation in two- and three-dimensional assay systems. Peptide arrays screened to identify regions critical for the IGFBP-3/-5:VN and IGF-II:VN interactions demonstrated IGFBP-3/-5 and IGF-II binds VN through the hemopexin-2 domain, and VN binds IGFBP-3 at residues not involved in the binding of IGF-I to IGFBP-3. IGFBP-interacting VN peptides identified from these peptide arrays disrupted the IGF-I:IGFBP:VN complex, impeded the growth of primary tumor-like spheroids and, more importantly, inhibited the invasion of metastatic breast cancer cells in 3D assay systems. These studies provide first-in-field evidence for the utility of small peptides in antagonizing GF:ECM-mediated biologic functions and present data demonstrating the potential of these peptide antagonists as novel therapeutics.]]> Mon 05 Sep 2022 09:43:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46873 7. Overall positive surgical margins (PSM) occurred in 15.9% with pT2 PSM 9.8%, pT3a PSM 30.8% and pT3b PSM 39.2%. Mean urinary continence at 12 months was 91.4% (data available from five surgeons). Mean 12 months potency after bilateral nerve spare was 47.2% (data available from four surgeons). Biochemical recurrence occurred in 10.6% (mean follow up 17 months). Conclusion: The Australian experience of Fellowship trained surgeons performing LRP demonstrates favourable peri-operative, oncological and functional outcomes in comparison to published data for open, laparoscopic and robotic assisted radical prostatectomy. In our Australian centres, LRP remains an acceptable minimally invasive surgical treatment for prostate cancer despite the increasing use of robotic assisted surgery.]]> Mon 05 Dec 2022 09:22:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42619 Mon 04 Sep 2023 13:58:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43398 Mon 04 Sep 2023 13:18:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48634 3.5-fold after steroid and ATG treatment. This case illustrates the need to consider this form of steroid resistance in patients failing treatment with corticosteroids. It also highlights the need for both better identification of patients at risk and the development of treatments that involve more specific immune suppression.]]> Mon 03 Apr 2023 10:14:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45453 Fri 28 Oct 2022 14:15:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42616 Fri 26 Aug 2022 15:54:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42611 Fri 26 Aug 2022 14:51:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43403 Fri 16 Sep 2022 10:05:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27572 Fri 10 Mar 2023 19:00:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18326 Fri 10 Mar 2023 18:53:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20126 Fri 10 Mar 2023 18:52:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28170 health system and information and patient care and support needs. Conclusion: These resources have the potential as an efficient and acceptable strategy for supporting needs-based cancer care. Further work is required to determine their unique contribution to improvements in patient outcomes.]]> Fri 10 Mar 2023 18:17:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25451 Fri 10 Mar 2023 18:02:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31413 Fri 10 Mar 2023 17:57:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9513 Fri 10 Mar 2023 17:45:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22664 n = 99) and descriptive (n = 83). Fourteen intervention studies met EPOC design criteria. Face-to-face interventions reported benefits for anxiety (5/7), satisfaction (1/1), knowledge (3/3) and health care costs (1/1). Audio-visual and multi-media interventions improved satisfaction (1/1) and knowledge (2/3), but not anxiety (0/3). Written interventions were mixed. Conclusion: Descriptive studies dominate the literature examining preoperative education in oncology populations, with few rigorous intervention studies. Pre-operative education can improve satisfaction, knowledge and reduce anxiety. Practice implications: Further work should be directed at multi-modal interventions, and those that include the caregiver, given their role in assisting patients to prepare and recover from surgery.]]> Fri 10 Mar 2023 17:42:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26667 Fri 10 Mar 2023 17:32:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10435 Fri 10 Mar 2023 17:26:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14024 Fri 10 Mar 2023 17:21:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25459 Fri 10 Mar 2023 17:11:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43014 Fri 09 Sep 2022 16:16:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42963 Fri 09 Sep 2022 09:53:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40254 Fri 08 Jul 2022 13:42:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44096 p < 0.001). After adjustment, there was no significant difference in referral to radiation oncology (intervention 32% vs control 30%; adjusted RR=1.06; 95% CI [0.74 to 1.51]; p=0.879). Sites with the largest relative increases in the percentage of patients discussed also tended to have greater increases in referral (p=0.001). In the intervention phase, urologists failed to provide referrals to more than half of patients whom the MDT had recommended for referral (78 of 140; 56%). Conclusions: The intervention resulted in significantly more patients being discussed by a MDT. However, the recommendations from MDTs were not uniformly recorded or followed. Although practice varied markedly between MDTs, the intervention did not result in a significant overall change in referral rates, probably reflecting a lack of change in urologists' attitudes. Our results suggest that interventions focused on structures and processes that enable health system-level change, rather than those focused on individual-level change, are likely to have the greatest effect.]]> Fri 07 Oct 2022 08:50:21 AEDT ]]>